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[Investigation of repeated marrow sampling from dogs]
1Toxicology Research Laboratories, Chugai Pharmaceutical Co., Ltd., Nagano, Japan.
Jikken Dobutsu. Experimental Animals
|April 1, 1993
Summary
Marrow aspiration in Beagle dogs showed no significant adverse effects on general health, hematology, or serum biochemistry over 30-day intervals. This technique is safe for safety studies involving dogs.
Area of Science:
- Veterinary Medicine
- Animal Hematology
- Biomedical Research
Context:
- Marrow aspiration is a critical procedure in preclinical safety studies.
- Evaluating the safety of repeated marrow aspiration in canine models is essential for ethical and reliable research.
- Beagle dogs are commonly used in toxicological and safety studies.
Purpose:
- To assess the safety and impact of repeated sternal marrow aspiration in Beagle dogs.
- To establish the feasibility of using this technique in longitudinal safety studies.
- To identify any potential adverse effects associated with the marrow aspiration procedure.
Summary:
- Four serial marrow aspirations were performed on Beagle dogs from the sternum at 30-day intervals.
- Evaluated parameters included general condition, body weight, body temperature, hematology, and bone marrow differential cell counts.
- Serum biochemical analysis, including creatine phosphokinase (CPK) activity, was also monitored.
Impact:
- The study demonstrates that repeated sternal marrow aspiration is well-tolerated in Beagle dogs.
- Findings support the use of this technique in canine safety studies without significant physiological disruption.
- Minimal changes, such as transient CPK elevation, suggest a safe profile for the marrow aspiration procedure.