[Investigation of repeated marrow sampling from dogs]

In order to apply a marrow aspiration technique to the safety study employing dog, a series of 4 marrow aspirations from the sternum of Beagle dog at intervals of 30 days were performed. No remarkable changes were observed in general conditions, body weight, body temperature, hematology and bone marrow differential cell counts. Except a temporal increase of CPK activity at day 1, no significant changes were also observed in serum biochemical analysis.