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Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase
1Department of Experimental Surgery, Istituto di Ricerca Codivilla-Putti I.O.R., Bologna.
Abstract:
The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.