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Autoantibodies in systemic lupus erythematosus
1Hospital for Special Surgery-Cornell University Medical Center, New York, New York, USA.
Current Opinion in Rheumatology
|September 1, 1995
Abstract:
Autoantibodies in systemic lupus erythematosus (SLE) are targeted predominantly to intracellular nucleoprotein particles. Following analysis of the quantitative and qualitative properties of the humoral immune response as well as identification of the major particles recognized as antigens, current studies are addressing the following questions: How is tolerance lost? What accounts for the selection of the antigens? What perpetuates the autoimmune response in SLE?