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Nonrheumatic conditions in children including infectious diseases and syndromes
1Division of Pediatric Rheumatology, Floating Hospital for Children, New England Medical Center, Boston, MA 02111, USA.
Insights
Pediatric rheumatologists often diagnose nonrheumatologic conditions in children. This review covers infections, inherited syndromes, and bony dysplasias affecting the musculoskeletal system.
Area of Science:
- Pediatric Rheumatology
- Infectious Diseases
- Genetics
Background:
- Many children referred to pediatric rheumatologists have nonrheumatologic conditions.
- Infections and genetic disorders can significantly impact the musculoskeletal system.
- Understanding these diverse conditions is crucial for accurate diagnosis and management.
Purpose of the Study:
- To review nonrheumatologic musculoskeletal disorders in children.
- To highlight infections, inherited syndromes, and bony dysplasias.
- To provide an overview of current clinical findings and genetic information.
Main Methods:
- Literature review of infectious causes of musculoskeletal symptoms.
- Review of inherited syndromes with musculoskeletal manifestations.
- Examination of bony dysplasias and rare syndromes affecting children.
Main Results:
- Infections like Yersinia, tuberculosis, and brucellosis can cause musculoskeletal issues.
- Reactive arthritis and changing clinical spectra of acute rheumatic fever are noted.
- Inherited syndromes and bony dysplasias present diverse musculoskeletal findings.
Conclusions:
- Nonrheumatologic conditions are common in pediatric rheumatology evaluations.
- Infections and genetic factors play a significant role in pediatric musculoskeletal health.
- Comprehensive review aids in diagnosing and managing diverse pediatric musculoskeletal disorders.
Abstract:
Often, a child is referred for evaluation to a pediatric rheumatologist and found to have a nonrheumatologic disorder. Infections constitute an important group of disorders with potential musculoskeletal system involvement. Reactive arthritis subsequent to infection with Yersinia is discussed, as well as reactive arthritis seen in the course of cystic fibrosis. Musculoskeletal manifestations of tuberculosis and brucellosis are reviewed. The continued presence of acute rheumatic fever in the United States has been documented, but the clinical spectrum of the disease appears to be changing over time. A variety of inherited syndromes may involve the musculoskeletal system, either primarily or as a minor manifestation. The bony dysplasias, another group of disorders, result from abnormal collagen structure and affect musculoskeletal development; clinical findings and new genetic information is reviewed. Descriptions of several rare syndromes (eg, hyaline fibromatosis and hypertrophic osteoarthropathy) also are reviewed here.
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