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p53 codon 213 (A-G) polymorphism in a Turkish population

I Ilhan1, S Erekul, S Ateşalp

  • 1Dr. Sami Ulus Children's Hospital, Ankara, Turkey.

Pediatric Hematology and Oncology
|September 1, 1995
PubMed
Summary

The p53 gene

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Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • The p53 tumor suppressor gene plays a critical role in preventing cancer.
  • Genetic variations, such as polymorphisms, can influence p53 function and cancer risk.
  • The CD 213 (A-G) polymorphism in exon 6 of the p53 gene is of interest due to its potential impact.

Purpose of the Study:

  • To investigate the frequency of the CD 213 (A-G) polymorphism in the p53 gene within a Turkish population.
  • To determine if this specific p53 gene polymorphism is associated with an increased risk of developing malignant lymphoma, osteosarcoma, or nasopharyngeal sarcoma.

Main Methods:

  • Genotyping was performed on DNA samples from a healthy Turkish cohort (n=26) and patients with various tumors (n=21).
  • Analysis focused on a specific polymorphism located at exon 6 (CD 213) of the p53 gene.
  • Allele frequencies were compared between healthy individuals and tumor patient groups.

Main Results:

  • The CD 213 (A-G) polymorphism was found to be extremely rare in the studied Turkish population.
  • The polymorphic allele was detected in only one individual with malignant lymphoma (4.16% frequency in this subgroup).
  • No statistically significant association was observed between the CD 213 (A-G) p53 polymorphism and the investigated tumor types.

Conclusions:

  • The CD 213 (A-G) polymorphism of the p53 gene is of very low frequency in the Turkish population.
  • Current data suggest that this specific p53 polymorphism is not a significant risk factor for malignant lymphoma, osteosarcoma, or nasopharyngeal sarcoma in this cohort.

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