Related Experiment Videos
Gastric cancer: prognosis and lymph node reactivity
A Di Giorgio1, C Botti, P Mingazzini
1Institute of Clinical Surgery, University of Rome, La Sapienza, Italy.
The European Journal of Surgery = Acta Chirurgica
|August 1, 1995
Summary
Prognostic value of immunomorphological variables in gastric cancer was assessed. Sinus histiocytosis and pTNM stage significantly correlated with patient survival after curative resection.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Gastric cancer prognosis after curative resection depends on various factors.
- Immunomorphological variables may offer prognostic insights.
Purpose of the Study:
- To evaluate the prognostic significance of diverse immunomorphological markers in gastric cancer patients undergoing curative resection.
Main Methods:
- Retrospective analysis of 180 gastric cancer patients treated between 1960-1978.
- Correlation of survival rates with nuclear grade, lymphocytic infiltration, and lymph node reactions (sinus histiocytosis, lymphoid hyperplasia).
Main Results:
- Overall 5- and 10-year survival rates were 46% and 36%.
- Tumor site, sex, and histology did not impact survival.
- Multivariate analysis identified pTNM stage and degree of sinus histiocytosis as significant prognostic factors.
Conclusions:
- Sinus histiocytosis emerged as a significant prognostic indicator in gastric cancer.
- The presence or absence of sinus histiocytosis could aid in stratifying patients for adjuvant therapy trials.