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[Nitric oxide in gastroenterology]

C Merino Ugarte1

  • 1Servicio de Gastroenterologia, Hospital Nacional G. Almenara I.

Revista De Gastroenterologia Del Peru : Organo Oficial De La Sociedad De Gastroenterologia Del Peru
|January 1, 1995
PubMed
Summary

Endothelium-derived relaxing factor (EDRF) has been identified as nitric oxide (NO), a molecule produced in the digestive tract and other organs. This discovery opens avenues for pharmacologic interventions targeting NO production for various medical conditions.

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Area of Science:

  • Physiology
  • Pharmacology
  • Gastroenterology

Background:

  • Endothelium-derived relaxing factor (EDRF) was identified as nitric oxide (NO).
  • Nitric oxide (NO) is produced in situ within the digestive tract and numerous other organs.
  • NO functions as a labile, humoral-like messenger, mediator, or regulator of cellular functions.

Purpose of the Study:

  • To explore the potential for pharmacologic control of conditions by modulating nitric oxide (NO) production.
  • To identify specific physiological conditions that could benefit from NO-targeted therapies.

Main Methods:

  • Identification of EDRF as NO.
  • In situ production analysis of NO in the digestive tract and other organs.
  • Review of existing literature, primarily from animal studies.

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Main Results:

  • Nitric oxide (NO) is endogenously produced in various tissues, including the digestive tract.
  • Pharmacologic manipulation of NO production is theoretically possible.
  • Numerous physiological conditions may be amenable to improved treatment through NO modulation.

Conclusions:

  • The identification of nitric oxide (NO) as EDRF provides a novel target for therapeutic intervention.
  • Conditions such as achalasia, endotoxin-induced cell injury, altered visceral blood flow, and decompensated cirrhosis may benefit from NO-based treatments.
  • Further research, particularly in human studies, is warranted to translate these findings into clinical practice.