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Insulin resistance in psoriasis

S L Brenelli1, A M Moraes, S Monte-Alegre

  • 1Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|March 1, 1995
PubMed
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Patients with psoriasis exhibit insulin resistance, indicated by higher insulin levels during glucose tolerance tests and impaired glucose uptake. This resistance also affects potassium regulation, suggesting broader metabolic dysfunction in psoriasis.

Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Dermatology

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Metabolic disturbances are increasingly associated with psoriasis.
  • Insulin resistance is a potential link between psoriasis and metabolic syndrome.

Purpose of the Study:

  • To investigate glucose and insulin metabolism in patients with psoriasis.
  • To assess insulin sensitivity using oral glucose tolerance tests (OGTT) and intravenous insulin tolerance tests (ITT).
  • To explore the impact of insulin resistance on potassium homeostasis in psoriasis.

Main Methods:

  • Oral glucose tolerance test (OGTT) and 15-minute intravenous insulin tolerance test (ITT) were performed.
  • Ten patients with psoriasis and 11 healthy controls participated.

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  • Plasma glucose, serum insulin, and serum potassium levels were measured.

    • Main Results:

    • No significant differences in plasma glucose levels were observed between groups.
    • Psoriatic patients showed significantly higher serum insulin levels during OGTT.
    • Patients with psoriasis had a lower glucose disappearance rate during ITT, indicating insulin resistance.
    • Reduced serum potassium reduction during ITT in psoriatic patients suggested impaired insulin action on potassium homeostasis.

    Conclusions:

    • Psoriasis is associated with significant insulin resistance affecting glucose metabolism.
    • Insulin resistance in psoriasis extends beyond glucose regulation, impacting potassium homeostasis.
    • These findings highlight a potential link between psoriasis, insulin resistance, and broader metabolic complications.