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Non specific resistance against malaria pre-erythrocytic stages: involvement of acute phase proteins
S Pied1, M D Tabone, G Chatellier
1INSERM U 313, Groupe Pitié-Salpêtrière, Paris, France.
Parasite (Paris, France)
|September 1, 1995
Abstract:
Levels of different acute phase proteins were compared in sera from parasitaemic and non-parasitaemic women living in a Plasmodium falciparum endemic area of Thailand. The ability of their sera to interfere with hepatic stage development of the parasite was examined. Correlations were found between levels of alpha-1 antitrypsin, alpha-2 macroglobulin, hemopexin and the potential of sera to block hepatocyte invasion by the sporozoite.