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Cholesteryl ester transfer proteins, reverse cholesterol transport, and atherosclerosis
Current Opinion in Lipidology
|October 1, 1995
Summary
Cholesteryl ester transfer protein (CETP) deficiency increases HDL-cholesterol, suggesting it
Area of Science:
- Lipid metabolism and cardiovascular research.
Background:
- Plasma cholesteryl ester transfer protein (CETP) facilitates the exchange of cholesteryl esters and triglycerides between lipoproteins.
- Human genetic CETP deficiency correlates with elevated HDL-cholesterol.
- CETP overexpression in mice leads to reduced HDL-cholesterol levels.
Purpose of the Study:
- To investigate the proposed antiatherogenic state associated with CETP deficiency.
- To explore the dual role of CETP expression in atherogenesis, considering its function in reverse cholesterol transport.
Main Methods:
- Analysis of human genetic CETP deficiency.
- Examination of CETP transgenic mouse models.
- Evaluation of CETP's role in reverse cholesterol transport.
Main Results:
- Human CETP deficiency is linked to increased HDL-cholesterol.
- CETP overexpression in mice results in decreased HDL-cholesterol.
- Emerging evidence suggests potential antiatherogenic effects of CETP expression.
Conclusions:
- The role of CETP in atherogenesis is complex and warrants further investigation.
- CETP's involvement in reverse cholesterol transport may confer protective effects against atherosclerosis.
- Contradictory findings highlight the need for a nuanced understanding of CETP's impact on cardiovascular health.