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[Toxic cholestatic hepatitis due to phenytoin]
C de la Serna Higuera1, L A Gil Grande, R Bárcena Marugán
1Servicio de Gastroenterología, Hospital Ramón y Cajal, Madrid.
Gastroenterologia Y Hepatologia
|November 1, 1995
Summary
Diphenylhydantoin (phenytoin) can cause severe liver injury, including toxic cholestatic hepatitis, in patients treated post-neurosurgery. Prompt drug withdrawal led to clinical recovery, though biochemical abnormalities lingered.
Area of Science:
- Hepatology
- Neurology
- Clinical Pharmacology
Background:
- Intracranial aneurysm surgery requires prophylactic treatment to prevent complications.
- Diphenylhydantoin (phenytoin) is commonly used for seizure prophylaxis.
- Drug-induced liver injury (DILI) is a significant concern in clinical practice.