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Cisplatin plus radiation therapy

R H Wheeler1, S Spencer

  • 1Department of Medicine, University of Alabama at Birmingham 35294, USA.

The Journal of Infusional Chemotherapy
|January 1, 1995
PubMed
Summary
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Advanced head and neck squamous cell cancer is challenging. Concomitant chemotherapy and radiation therapy show promise for improved local control, but further trials are needed to confirm survival benefits and optimal treatment strategies.

Area of Science:

  • Oncology
  • Head and Neck Cancer Treatment

Background:

  • Advanced-stage head and neck squamous cell carcinoma presents a significant therapeutic challenge.
  • Locoregional relapse and distant metastases are common, leading to poor patient survival despite aggressive treatments.

Purpose of the Study:

  • To evaluate the efficacy and safety of concomitant chemotherapy and radiation therapy for advanced head and neck cancer.
  • To explore the potential benefits of combined treatment over standard therapies.

Main Methods:

  • Review of clinical trials investigating neoadjuvant chemotherapy and concomitant chemoradiation.
  • Analysis of treatment outcomes, including local control, distant metastasis, and survival rates.

Main Results:

  • Neoadjuvant chemotherapy reduces distant metastasis but does not improve local control or survival.

Related Experiment Videos

  • Concomitant chemoradiation, particularly with cisplatin and 5-fluorouracil, suggests improved local control.
  • Randomized studies confirming survival benefits and justifying increased toxicity are pending.

    • Conclusions:

    • Concomitant chemoradiation offers a theoretical advantage for local control in advanced head and neck cancer.
    • Further research is required to establish definitive survival benefits and optimize treatment regimens, including cisplatin dosing and novel agents.