Chemical measurements of inulin concentrations in peritoneal dialysis solution

Peritoneal inulin clearance during peritoneal dialysis is a useful indicator of efficiency of removal of larger solutes. Peritoneal dialysis solutions usually contain high glucose concentrations that interfere with the chemical measurements of inulin concentration. In these studies, inulin recoveries in simple glucose and peritoneal dialysis solutions with three chemical methods were compared; all methods reportedly were subject to minimal glucose interference. The findings showed one method subject to minimal and predictable glucose interference in all solutions tested. For two methods, interference in peritoneal dialysis solutions exceeded that predicted from glucose alone; this unexpected interference was shown to most likely result from carmalized glucose subsequent to the routine autoclaving of peritoneal dialysis solutions.