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Delayed rectifier channels in human ventricular myocytes

M W Veldkamp1, A C van Ginneken, T Opthof

  • 1Department of Physiology, University of Amsterdam, The Netherlands.

Circulation
|December 15, 1995
PubMed
Summary
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This study identifies the rapidly activating component of the delayed rectifier potassium current (IKr) in human ventricular myocytes. Findings confirm IKr

Area of Science:

  • Cardiovascular Physiology
  • Ion Channel Electrophysiology

Background:

  • The heart possesses two distinct delayed rectifier potassium currents: rapidly activating (IKr) and slowly activating (IKs).
  • The presence of IKr and IKs varies by species.

Purpose of the Study:

  • To investigate the characteristics of the delayed rectifier current in human ventricular tissue.
  • To determine if IKr is present in the human ventricle.

Main Methods:

  • Whole-cell and single-channel patch-clamp recordings from human ventricular myocytes.
  • Analysis of voltage-dependent activation and ion selectivity of identified K+ channels.
  • Pharmacological blockade using the IKr-specific drug E-4031.

Main Results:

Related Experiment Videos

  • A voltage-dependent potassium channel was identified with properties consistent with IKr.
  • Channel activation was time- and voltage-dependent, with a time constant of 101 ms at +30 mV.
  • E-4031 completely blocked channel activity, confirming its identity as IKr.
  • No evidence for the presence of IKs was found.

    • Conclusions:

    • The characterized K+ channel in human ventricle exhibits properties matching IKr.
    • These findings strongly suggest the presence of IKr in the human ventricle.