Pseudohyperphosphatemia
Related Experiment Video
Updated: Nov 6, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
1University of Cambridge Department of Anatomy, United Kingdom.
Objective:
To review instances of spurious elevation of inorganic phosphate measurements due to interference with analytical methods.
Methods:
SElective literature review.
Results:
Depending on the method used to measure inorganic phosphate, several factors have been reported to produce spurious elevations, including paraproteinemia, hyperlipidemia, hemolysis, and hyperbilirubinemia. Of these, paraproteinemia is probably the commonest.
Conclusion:
Both clinical biochemists and clinicians should be aware of the phenomenon of pseudohyperphosphatemia. Clinically unexplained persistent hyperphosphatemia should initiate a search for potential causes of pseudohypophosphatemia, especially paraproteinemia.
Related Concept Videos
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily regulated...
Chronic Kidney Disease II: Clinical Manifestations
Phosphate Buffer
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
Skeleton and Calcium Homeostasis
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
