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Pseudohyperphosphatemia

A J Larner1

  • 1University of Cambridge Department of Anatomy, United Kingdom.

Clinical Biochemistry
|August 1, 1995
PubMed
Summary

Pseudohyperphosphatemia, a spurious elevation in inorganic phosphate, can be caused by analytical interferences. Paraproteinemia is a common cause that requires clinical awareness.

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Area of Science:

  • Clinical Biochemistry
  • Analytical Chemistry

Background:

  • Inorganic phosphate levels are crucial for diagnosing various metabolic and renal disorders.
  • Accurate measurement of inorganic phosphate is essential for correct clinical decision-making.

Purpose of the Study:

  • To review known instances of spurious elevation in inorganic phosphate measurements.
  • To identify analytical interferences that lead to falsely high phosphate readings.

Main Methods:

  • A selective literature review was conducted.
  • The review focused on analytical interferences affecting inorganic phosphate assays.

Main Results:

  • Spurious elevations in inorganic phosphate can result from paraproteinemia, hyperlipidemia, hemolysis, and hyperbilirubinemia.
  • Paraproteinemia is identified as the most frequent cause of pseudohyperphosphatemia.
  • The specific analytical method employed influences the likelihood of interference.

Conclusions:

  • Clinical biochemists and clinicians must recognize the phenomenon of pseudohyperphosphatemia.
  • Unexplained persistent hyperphosphatemia warrants investigation for potential causes of pseudohyperphosphatemia, particularly paraproteinemia.

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