Related Experiment Video
Updated: Jul 18, 2026
05:53
Intraoperative Ultrasound in Spinal Surgery
Published on: August 17, 2022
Spinal epidural malignant lymphoma presenting with spinal cord compression
1Department of Neuropathology, Brook General Hospital, London, UK.
Clinical Neuropathology
|July 1, 1995
Abstract:
Malignant lymphoma initially presenting with symptoms and signs of spinal cord compression are a rare occurrence. We present 20 cases of spinal epidural lymphoma first diagnosed on laminectomy biopsy specimens with a review of clinical data and histology, as well as an immunohistochemical study to determine the immunophenotype of these lymphomas. Eighteen cases were typed as B cell lymphomas, 2 as T cell lymphomas.
Related Concept Videos
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
01:29Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...