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Moyamoya disease in twins
Clinical Nuclear Medicine
|September 1, 1995
Summary
Technetium Tc-99m HMPAO SPECT imaging effectively detects reduced cerebral blood flow in moyamoya disease. This method correlates well with clinical symptoms and angiographic findings, aiding diagnosis.
Area of Science:
- Neurology
- Nuclear Medicine
- Radiology
Background:
- Moyamoya disease is a rare cerebrovascular disorder characterized by progressive stenosis of the internal carotid arteries.
- Accurate assessment of regional cerebral blood flow is crucial for understanding disease progression and guiding treatment.
Observation:
- Technetium Tc-99m hexamethylpropyleneamine oxime (HMPAO) single-photon emission computed tomography (SPECT) was utilized to assess cerebral perfusion.
- Studies were conducted on a monozygotic twin pair, one of whom had angiographically confirmed moyamoya disease.
Findings:
- Both patients exhibited focal and global reductions in regional cerebral perfusion on Tc-99m HMPAO SPECT.
- A strong correlation was found between the location and severity of perfusion abnormalities and the clinical stage of moyamoya disease as seen on angiography.
Implications:
- Tc-99m HMPAO SPECT is a valuable tool for detecting hemodynamic disturbances in moyamoya disease.
- This imaging modality can aid in the diagnosis and management of patients with moyamoya disease.