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Nutritional status and growth hormone-binding protein
M C Postel-Vinay1, C Saab, M Gourmelen
1INSERM Unité 344, Faculté de Médecine Necker, Paris, France.
Hormone Research
|January 1, 1995
Summary
Nutrition significantly impacts growth hormone (GH) receptor levels. Poor nutrition, like in anorexia nervosa and celiac disease, lowers GH-binding protein, while obesity increases it, affecting growth.
Area of Science:
- Endocrinology
- Nutritional Science
- Pediatrics
Background:
- Nutrition plays a crucial role in regulating growth hormone (GH) receptor status.
- Understanding the relationship between nutritional status and GH receptor function is vital for diagnosing and treating growth disorders.
Purpose of the Study:
- To investigate the impact of varying nutritional states on plasma GH-binding protein levels.
- To explore the correlation between GH-binding protein, body mass index (BMI), and insulin-like growth factor-1 (IGF-1) in different patient groups.
Main Methods:
- Plasma GH-binding protein levels were measured in patients with anorexia nervosa, celiac disease, and severe obesity.
- Body weight, height, and BMI were recorded for all participants.
- Correlation analyses were performed between GH-binding protein, BMI, and IGF-1 levels.
Main Results:
- GH-binding protein was significantly low in patients with anorexia nervosa and celiac disease.
- GH-binding protein levels were markedly elevated in severely obese children.
- A strong positive correlation was observed between GH-binding protein and BMI, as well as with IGF-1 levels.
Conclusions:
- Nutritional status is a key regulator of the GH receptor/binding protein system.
- Undernourished children experience growth failure due to partial GH resistance and reduced GH receptor levels.
- Obese children with normal growth exhibit high GH receptor levels, suggesting a complex interplay between nutrition, GH signaling, and growth.