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Serum TNF-alpha, sCD8 and sIL-2R levels in childhood tuberculosis
I B Barlan1, M M Başaran, M Bakir
1Dept. of Pediatrics, Marmara Univ. Hospital, Istanbul, Turkey.
Infection
|July 1, 1995
Abstract:
In this study we have determined the serum tumor necrosis factor-alpha (TNF-alpha), soluble CD8 (sCD8) and soluble interleukin-2 receptor (sIL-2R) levels in children with active pulmonary tuberculosis (n = 66) and healthy controls (n = 20). Measurable serum TNF-alpha levels were detected in nine of 86 children (10.5%), all of whom belonged to the group with active disease. Serum sCD8 and sIL-2R determinations revealed a significant difference between the group with active pulmonary tuberculosis and the controls (p < 0.05). Deeper insight into the involvement of cytokines and T cells will provide a better understanding