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Hemostatic risk factors of coronary artery disease in the Chinese
Insights
Higher levels of fibrinogen and factor VII, but not plasminogen activator inhibitor, are linked to coronary artery disease (CAD) in Chinese individuals. These hemostatic factors may serve as key indicators for identifying at-risk populations.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Epidemiology
Background:
- Coronary artery disease (CAD) poses a significant health burden globally.
- Identifying hemostatic risk factors is crucial for understanding CAD pathogenesis.
- Previous research has explored various coagulation parameters in relation to cardiovascular health.
Purpose of the Study:
- To investigate hemostatic risk factors for coronary artery disease (CAD) specifically within the Chinese population.
- To compare levels of specific hemostatic markers between healthy controls, diabetic patients, and CAD patients.
Main Methods:
- Assessed antithrombin III concentration, factor VII, fibrinogen, plasminogen activator inhibitor-1 antigen, and platelet count.
- Included 51 healthy controls, 55 diabetics, and 56 patients with arteriographically proven CAD.
- Analyzed data based on disease severity (single, double, triple vessel disease) and history of myocardial infarction.
Main Results:
- Fibrinogen and factor VII levels were significantly elevated in CAD patients compared to both controls and diabetics (P = 0.0001).
- No significant differences in hemostatic parameters were observed between diabetics and controls.
- No significant variations in these parameters were found based on CAD severity or myocardial infarction history within the CAD group.
Conclusions:
- Elevated fibrinogen and factor VII are identified as significant hemostatic risk factors for coronary artery disease in the Chinese.
- Plasminogen activator inhibitor-1 was not found to be a significant risk factor in this population.
- These findings highlight the importance of monitoring fibrinogen and factor VII for CAD risk assessment in Chinese individuals.
Abstract:
In order to find out the hemostatic risk factors of coronary artery disease in the Chinese, antithrombin III concentration, factor VII and fibrinogen assays, plasminogen activator inhibitor-1 antigen and platelet count were determined in 51 healthy controls (mean age 63.5 years, S.D. 10.3), 55 diabetics (mean age 66.0 years, S.D. 4.8) and 56 patients with arteriographically proved coronary artery disease (mean age 63.8 years, S.D. 8.7). Of the coronary artery disease group, 19 had single vessel disease, 21 had double vessel disease and 16 had triple vessel disease. Sixteen of this group also had a past history of myocardial infarction. There was no significant difference of the hemostasis parameters between diabetics and controls. Fibrinogen and factor VII, but not plasminogen activator inhibitor, were significantly higher in coronary artery disease patients than in controls (P = 0.0001, both) and in diabetics (P = 0.0001, both). No significant difference in the parameters was found in the coronary artery disease group, whether the patients had single vessel disease, double vessel disease, or triple vessel disease, or were with or without past myocardial infarction. In the myocardial infarction group, fibrinogen and factor VII were significantly higher than in the controls (P < 0.00005 and 0.0001, respectively) and in the diabetics (P = 0.0002 and 0.0004, respectively). We suggest that increased levels of fibrinogen and factor VII, but not plasminogen activator inhibitor, would be the hemostatic risk factors of coronary artery disease in the Chinese.