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Programmed cell death in development

E J Sanders1, M A Wride

  • 1Department of Physiology, University of Alberta, Edmonton, Canada.

International Review of Cytology
|January 1, 1995
PubMed
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Programmed cell death, or apoptosis, is crucial for embryonic development and differentiation. This review explores its mechanisms and occurrence in both invertebrate and vertebrate embryos, including limb and nervous system development.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Cell death is a known factor in embryonic morphogenesis.
  • Recent advances in developmental genetics and immunology illuminate cell death mechanisms.
  • Programmed cell death plays a role in cell lineages, particularly in invertebrates.

Purpose of the Study:

  • To review programmed cell death in developmental contexts.
  • To explore the relationship between programmed cell death and apoptosis.
  • To discuss the occurrence and detection of apoptosis in developing organisms.

Main Methods:

  • Literature review of programmed cell death in developmental situations.
  • Description of morphological and biochemical features of apoptosis.

Related Experiment Videos

  • Overview of methods for detecting apoptosis in tissues.

    • Main Results:

    • Programmed cell death is integral to embryonic development and differentiation.
    • Apoptosis, a key form of programmed cell death, has distinct features and detection methods.
    • Programmed cell death is observed across invertebrate and vertebrate development.

    Conclusions:

    • Programmed cell death is a fundamental process in embryonic morphogenesis.
    • Understanding apoptosis mechanisms is key to understanding developmental processes.
    • Further research into cell death in specific vertebrate systems (early embryo, limbs, nervous system) is warranted.