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Drug abuse proficiency testing

G O Guerrant, C T Hall

    Clinical Toxicology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Proficiency testing significantly improves drug detection, especially for methamphetamine. However, many labs struggle with accurately screening for benzoylecgonine, a key cocaine metabolite, indicating a need for better drug testing proficiency.

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    Area of Science:

    • Forensic toxicology
    • Analytical chemistry

    Background:

    • Proficiency testing (PT) is crucial for ensuring accuracy in clinical and forensic laboratories.
    • Technological advancements and structured PT programs contribute to improved analytical performance.

    Purpose of the Study:

    • To evaluate the impact of proficiency testing on drug detection accuracy.
    • To identify specific areas where laboratory performance needs improvement in drug screening.

    Main Methods:

    • Analysis of proficiency testing data across multiple surveys.
    • Comparison of laboratory performance trends for various drugs and metabolites over time.

    Main Results:

    • Significant improvements in the detection of morphine, methadone, and methamphetamine were observed, linked to PT participation.

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  • Consistently poor performance was noted in the proficiency testing for benzoylecgonine, a primary cocaine metabolite, indicating widespread issues in cocaine abuse screening.

    • Conclusions:

    • Proficiency testing is a powerful driver for enhancing analytical accuracy in drug detection.
    • Specific challenges remain, particularly in the accurate screening for cocaine metabolites, highlighting a critical need for targeted interventions and improved laboratory proficiency in this area.