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Epilarynx: pharynx or larynx?

J L Lefebvre1, E Buisset, B Coche-Dequeant

  • 1Head and Neck Department, Centre Oscar Lambret, Lille, France.

Head & Neck
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

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The epilarynx, often studied separately in France, shows distinct characteristics from other larynx cancers. This research supports its classification as a unique entity for clinical trial stratification.

Area of Science:

  • Otolaryngology
  • Oncology
  • Head and Neck Cancer Research

Background:

  • The epilarynx is typically analyzed as part of the supraglottis.
  • French classification often distinguishes the epilarynx due to its unique natural history.

Purpose of the Study:

  • To evaluate the French classification of epilarynx.
  • To compare epilarynx squamous cell carcinoma (SCC) with oropharynx, hypopharynx, and vestibule SCC from epidemiologic and clinical perspectives.

Main Methods:

  • Epidemiologic comparison: 86 epilarynx SCC cases vs. 431 oropharynx, 339 hypopharynx, 89 vestibule SCC.
  • Clinical comparison: 232 epilarynx SCC cases vs. 1351 oropharynx, 652 hypopharynx, 372 vestibule SCC.

Main Results:

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  • Epilarynx patients exhibited higher alcohol consumption than larynx patients, similar to pharynx patients; tobacco use was comparable.
  • Nodal involvement patterns for epilarynx SCC mirrored pharynx SCC.
  • Treatment outcomes and survival rates differed, with epilarynx SCC showing a 5-year survival of 27% compared to vestibule (43%) and pharynx (13%).
  • Epilarynx SCC demonstrated a lower incidence of lung cancers, aligning it more with pharynx SCC regarding multiple primary tumors.

    • Conclusions:

    • The findings advocate for recognizing the epilarynx as a distinct entity.
    • This classification is crucial for accurate stratification in clinical trials for head and neck cancers.