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Corrected gene assignments of Escherichia coli pro- mutations

I Serebrijski1, O Reyes, G Leblon

  • 1Laboratory of Genetics of Methylotrophic Microorganisms, Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia.

Journal of Bacteriology
|December 1, 1995
PubMed

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Overview
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Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...