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Subconjunctival hyaluronidase injection producing temporary myopia

Journal of Cataract and Refractive Surgery

|July 1, 1995

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A subconjunctival hyaluronidase injection caused temporary myopia in a patient. The induced myopia resolved spontaneously within 45 days without intervention.

Area of Science:

Ophthalmology
Pharmacology

Background:

Subconjunctival injections are used to treat various ocular conditions.
Hyaluronidase is an enzyme that breaks down hyaluronic acid, often used to increase tissue permeability.

Observation:

A 30-year-old female received a subconjunctival hyaluronidase injection to manage post-coughing hemorrhaging.
Following the injection, the patient developed myopia.

Findings:

The induced myopia was transient and resolved spontaneously.
Resolution of myopia occurred within 45 days of the initial event.
No specific treatment was administered for the induced myopia.

Implications:

This case highlights a potential, albeit temporary, adverse effect of subconjunctival hyaluronidase.

Related Experiment Videos

It suggests that the eye may have mechanisms for self-correction of refractive changes induced by such treatments.

Further investigation may be warranted to understand the precise mechanism of hyaluronidase-induced myopia.