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Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?
P Pickkers1, M Schachter, P S Sever
1Department of Clinical Pharmacology, Queen Elizabeth the Queen Mother Wing, St. Mary's Hospital Medical School, Imperial College of Science Technology and Medicine, London, UK.
Journal of Human Hypertension
|August 1, 1995
Abstract:
Thiazide diuretics are widely used to treat hypertension, but their use is associated with impaired glucose tolerance. We propose that the diabetogenic action of thiazides may be due to their ability to open calcium-activated potassium (KCa) channels in pancreatic beta-cells.