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Nisoldipine improves ventricular function in rats with ischemic heart failure

J M Capasso1

  • 1Department of Anatomy and Structural Biology, University of South Dakota School of Medicine, Vermillion 57069, USA.

Journal of Molecular and Cellular Cardiology
|September 1, 1995
PubMed
Summary

Nisoldipine, a calcium channel blocker, effectively prevented cardiac dysfunction in rats with ischemic heart failure. Early treatment with nisoldipine ameliorated the detrimental effects of coronary artery narrowing on heart function.

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Area of Science:

  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Ischemic heart failure can lead to a decompensated ventricle.
  • The role of transsarcolemmal calcium transport in this process requires further investigation.

Purpose of the Study:

  • To determine the effectiveness of calcium channel blockade in preventing cardiac dysfunction in ischemic heart failure.
  • To examine the impact of nisoldipine on transsarcolemmal calcium transport in a rat model of global cardiac ischemia.

Main Methods:

  • Rats underwent surgical narrowing of the left main coronary artery to induce global cardiac ischemia.
  • Animals were treated with nisoldipine (10 mg/kg) or water for one month.
  • Cardiac function parameters, including pressures and cardiac output, were measured.

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Main Results:

  • Coronary artery narrowing led to increased kidney and lung weights, and heart weights in water-treated rats.
  • Water-treated rats showed reduced systolic pressures, elevated diastolic pressures, and decreased cardiac output.
  • Nisoldipine treatment prevented these detrimental effects, with measured parameters intermediate between controls and water-treated rats.

Conclusions:

  • Calcium channel blockade with nisoldipine is therapeutic in preventing cardiac dysfunction and failure following ischemic heart disease in rats.
  • Early and continuous treatment with nisoldipine ameliorates the adverse impacts of ischemic heart disease.