Mood elevating effect of trihexyphenidyl and biperiden in individuals taking antipsychotic medication

The author calls attention to mood-elevation as a side effect of Biperiden HCL and Trihexyphenidyl HCL, two anticholinergic antiparkinsonian agents. This is of significance because of the despondency and anergy often seen in schizophrenics taking antipsychotic medication and because of the difficulty discerning the origin of affective changes in the face of polypharmacy.