[Diagnosis of Cushing's disease in pregnancy]

The Cushing syndrome during pregnancy is very infrequent, being even more so that of hypophysary etiology despite corticotropic adenomas being more prevalent in fertile-aged women. Its diagnosis is difficult since it may be confused with the physiologic alterations of the cortisol and the ACTH which occur during pregnancy. The treatment is controversial. In the cases reported to date, pregnancy represented a worsening of the picture. The case of a patient diagnosed with Cushing disease during the first trimester of pregnancy is presented. The hypercorticism improved clinically and biochemically during the pregnancy with no maternofetal complications observed. The disease activity continued following delivery.