[Antifungal activity of fluconazole in vitro]

The susceptibility of 97 fungal strains to fluconazole was evaluated using the dilution method. Forty-three of the strains were C. albicans, fifty-three other Candida species and one S. cerevisiae. The MIC values varied from 0.1 mg/l to 100 mg/l. However, the growth of 75.2% of the strains was considerably inhibited at 0.1 mg/l. Forty-nine strains were tested using both the dilution and disk-diffusion methods. The findings were consistent. The latter method may be performed on YNB medium and is of practical value.