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Inhibition by capsaicin against cyclophosphamide-induced clastogenicity and DNA damage in mice
A K De1, K Agarwal, A Mukherjee
1Department of Biochemistry, University College of Science, Calcutta, India.
Mutation Research
|December 1, 1995
Abstract:
We have demonstrated in an earlier paper that capsaicin, the pungent principle of red hot chili, has a potent anti-oxidant property that interferes with free-radical involved mechanisms. In the present paper we demonstrate that capsaicin significantly inhibits cyclophosphamide-induced (i.p.) chromosomal aberrations and DNA strand breakages. This protective action of capsaicin against CP-induced toxicity may possibly be linked with its already reported 'desensitisation' effect against chemical irritant-induced damages.