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Pemphigus vulgaris and pregnancy
1Department of Obstetrics and Gynecology, Poriya Hospital, Tiberias, Israel.
Obstetrical & Gynecological Survey
|October 1, 1995
Summary
Pemphigus vulgaris (PV) in pregnancy is rare. While neonatal skin lesions from antibody transfer are usually transient, severe maternal PV can risk poor pregnancy outcomes like prematurity or fetal death.
Area of Science:
- Dermatology
- Immunology
- Obstetrics
Background:
- Pemphigus vulgaris (PV) is a rare autoimmune blistering disease.
- Pregnancy and PV is infrequently documented in medical literature.
- Understanding PV's impact on pregnancy is crucial for maternal and fetal health.
Observation:
- Two women with PV experienced three pregnancies.
- Neonatal outcomes were generally favorable, with one infant showing transient PV skin lesions.
- Maternal PV can lead to poor neonatal outcomes, including prematurity and fetal death, particularly in severe cases.
Findings:
- Neonatal PV skin lesions result from passive transplacental antibody transfer and typically resolve spontaneously.
- Contrary to previous beliefs, severe maternal PV is linked to adverse pregnancy outcomes.
- Pregnancy outcomes in PV appear correlated with the clinical severity of the maternal disease.
Implications:
- PV management during pregnancy requires careful consideration of maternal disease severity.
- Increased awareness of potential neonatal complications in severe maternal PV is warranted.
- Further research into the pathophysiology of PV in pregnancy may improve patient outcomes.