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Updated: Aug 15, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
[Allogeneic transplantation of stem cells--procedure and biological aspects]
1Kirurgisk avdeling B, Rikshospitalet, Oslo.
Abstract:
The biological challenges to be overcome for allogeneic stem cell transplantation to succeed include: 1, eradication of the patient's malignant tissue by effective, yet tolerable cytoreductive preconditioning; 2, suppression of the patient's immunocompetence to prevent graft rejection; 3, a stem cell graft of adequate haematopoietic capacity must be obtained from a donor of acceptable histocompatibility, and transferred to the patient; and 4, since the graft also contains lymphocytes mediating antirecipient donor alloimmunity, posttransplant immunosuppressive therapy is required to prevent, and sometimes to treat graft-versus-host disease. Basic immunobiological and clinical aspects, and methods used in stem cell transplantation are reviewed in the article.
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