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Verapamil-induced "primary" polydipsia

I D Schwartz¹, D Scagliotti

¹Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO, USA.

Pediatric Cardiology

|September 1, 1995

Summary

Verapamil, used for supraventricular tachycardia (SVT), may cause primary polydipsia in infants. This behavioral change, marked by increased thirst and urination, resolved after discontinuing the medication.

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Area of Science:

Pediatric Cardiology
Clinical Pharmacology

Background:

Supraventricular tachycardia (SVT) is a common arrhythmia in infants.
Verapamil is a calcium channel blocker frequently used to manage SVT.

Observation:

An infant treated with oral verapamil for recurrent SVT developed behavioral changes.
Symptoms included lethargy, excessive thirst and urination (polydipsia), and irritability.

Findings:

The infant was diagnosed with primary polydipsia after ruling out other conditions like diabetes insipidus and mellitus.
Resolution of symptoms occurred one week after verapamil cessation.

Implications:

This case highlights a potential adverse effect of verapamil in infants.
Clinicians should consider verapamil-induced polydipsia in infants presenting with these symptoms.

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