Some effects of ORG GC 94, a potential anti-migraine drug, on human platelets

Some effects of Org GC 94 (1,3,4,14b-tetrahydro-2,7-dimethyl-2H-dibenzo[b,f]pyrazino[1,2-d][1,4]oxazepine maleate) on human platelets have been investigated. Without pretreatment with ADP, 5-HT-induced aggregation of humam platets was completely inhibited by 2.5 x 10(-8) M of Org GC 94. Aggregation triggered by noradrenaline (2.5 x 10(-5) M) and uptake of 5-HT by human platelets were inhibited only at the high concentrations of 10(-5) and 10(-4) M of Org GC 94 respectively. Up to millimolar concentrations, Org GC 94 did not liberate lactate dehydrogenase from human platelets. Org GC 94 did not block the oxidative deamination of benzylamine by human platelet rich plasma up to 2.5 x 10(-4) M.