Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxia-inducible gene expression

J Fandrey1

  • 1Physiologisches Institut 1, Rheinische Friedrich-Wilhelms-Universität Bonn Nussallee 11, Germany.

Respiration Physiology
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bringing European physiologists together.

Acta physiologica (Oxford, England)·2018
Same author

Membrane traffic control by hypoxia.

Acta physiologica (Oxford, England)·2017
Same author

[Erythropoiesis: Physiology, pathophysiology, and algorithm for classification of the type of anemia].

Der Internist·2015
Same author

Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis.

Mucosal immunology·2015
Same author

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia.

Leukemia·2014
Same author

Type I cell ROS kinetics under hypoxia in the intact mouse carotid body ex vivo: a FRET-based study.

American journal of physiology. Cell physiology·2014

Hypoxia, or low oxygen, triggers increased gene expression for crucial proteins like erythropoietin. This oxygen-sensing mechanism is widespread in mammals and shares similarities with bacterial systems.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Cellular production of hormones, cytokines, and enzymes increases under hypoxia.
  • Hypoxia-inducible gene expression is studied via the erythropoietin gene.
  • Oxygen-sensitive enhancer elements regulate gene transcription.

Purpose of the Study:

  • To understand how gene transcription is upregulated under hypoxic conditions.
  • To investigate the widespread nature of hypoxia-inducible enhancers in mammalian cells.
  • To compare mammalian oxygen-sensing mechanisms with bacterial systems.

Main Methods:

  • Studying the hypoxia-inducible expression of the erythropoietin gene.
  • Analyzing oxygen-sensitive enhancer elements.

Related Experiment Videos

  • Comparing mammalian and bacterial oxygen sensor systems.

    • Main Results:

    • Hypoxia increases gene expression for specific proteins via enhanced transcription.
    • Transcription factors bind to regulatory DNA sequences in response to hypoxia.
    • A widespread oxygen-sensing mechanism involving hypoxia-inducible enhancers exists in mammals.

    Conclusions:

    • The study elucidates a conserved oxygen-sensing mechanism in mammals.
    • Hypoxia-inducible enhancers play a critical role in regulating gene expression.
    • Similarities exist between mammalian and bacterial oxygen sensing pathways.