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Antimicrobial therapy in Plesiomonas shigelloides-associated diarrhea in Thai children
1Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Insights
Antibiotics did not significantly alter fever or diarrhea duration in Thai children with Plesiomonas shigelloides (P. shigelloides) infections. This study found no clinical benefit from antibiotic use in treating P. shigelloides-associated diarrhea.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Plesiomonas shigelloides (P. shigelloides) is a recognized cause of bacterial gastroenteritis.
- Antibiotic treatment is commonly considered for bacterial diarrhea, but its efficacy for P. shigelloides is not well-established.
Purpose of the Study:
- To evaluate the clinical effectiveness of antibiotic therapy in children with P. shigelloides-associated diarrhea.
- To compare the duration of fever and diarrhea in children who received antibiotics versus those who did not.
Main Methods:
- A retrospective case-controlled study involving 36 Thai children diagnosed with P. shigelloides-associated diarrhea.
- Patients were divided into two groups: 19 treated with antibiotics and 17 controls who received no antibiotics.
- Demographic and clinical data, including fever duration and diarrhea severity, were compared between groups.
Main Results:
- Antibiotic susceptibility testing showed high efficacy of quinolones and cephalosporins against P. shigelloides isolates.
- Conversely, only 9% of isolates were susceptible to ampicillin, while others like co-trimoxazole and gentamicin showed high susceptibility.
- No statistically significant difference (p > 0.05) was observed in the duration of fever or diarrhea between the antibiotic-treated group and the control group.
Conclusions:
- Antibiotic administration did not demonstrate a significant impact on the duration of fever or diarrhea in Thai children with P. shigelloides-associated diarrhea.
- The findings suggest that supportive care may be sufficient for managing P. shigelloides gastroenteritis in this pediatric population.
- Further research could explore specific antibiotic regimens or alternative treatments if indicated.
Abstract:
A retrospective case-controlled study was performed in 36 Thai children with Plesiomonas shigelloides (P. shigelloides)-associated diarrhea admitted to the Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University from August 1990 to December 1992. Nineteen cases received antibiotics while seventeen did not receive any. The two groups were comparable in age, sex, duration of fever, duration and severity of diarrhea and medical treatment. The antibiotics given were norfloxacin, wintomylon, colistin, gentamicin, ceftriaxone, co-trimoxazole and ampicillin. In our study, 100% of P. shigelloides isolates were susceptible to quinolones and cephalosporins, while only 9% were susceptible to ampicillin. Co-trimoxazole, gentamicin, netilmicin, chloramphenicol and nalidixic acid showed high susceptibility. The duration of fever and diarrhea after treatment was not significantly different between treatment and control groups (p > 0.05). Therefore, we conclude that antibiotics did not change the duration of fever and diarrhea in Thai children with P. shigelloides-associated diarrhea.