[Distribution of different groups of indirect sympathomimetics between aqueous and "fatty" phases]

Ionization constants were measured and distribution between the "fatty" and aqueous phases of the drugs (amphetamine, ephedrin, tyramine, methylphenidate, pipradrol), belonging to two groups of indirect sympathomimetics differing in the mechanism of their action, was studied. The lipophilic nature of the study compounds is shown to correlate with some pharmacological properties determining the difference in action produced by these drugs.