[Antibodies to mediators of inflammation as its inhibitors and analyzers]

Experiments with rabbits showed the formation of antibodies in response to introduction of histamine-, serotonin-, kalllikrein-, bradykinin-proteinic conjugates. The influence of antibodies on the exudative reaction following introduction of histamine, serotonin, kallikrein, bradykinin, dextran and agar to rats was studied. The ability of antibodies to block both the introduced from outside specific mediators of inflammation and their natural analogues is demonstrated. This bears proof to the possibility of utilizing the specific antibodies in the study of the mediating structure common to various types of inflammation and for the regulation of the inflammatory process.