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Smoking as a risk factor for duodenal ulcer relapse. RUDER Study Group

B D Breuer-Katschinski1, D Armstrong, H Goebell

  • 1Division of Gastroenterology, University of Essen, Germany.

Zeitschrift Fur Gastroenterologie
|September 1, 1995
PubMed
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Smoking significantly increases duodenal ulcer relapse rates during ranitidine treatment. Quitting smoking during maintenance therapy substantially reduces relapse risk, highlighting smoking cessation

Area of Science:

  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Duodenal ulcers are a common gastrointestinal condition.
  • Maintenance therapy with ranitidine is used to prevent ulcer recurrence.
  • Smoking is a known risk factor for various health conditions, but its specific impact on ulcer relapse during treatment requires further elucidation.

Purpose of the Study:

  • To investigate the influence of smoking status on the two-year relapse rate of duodenal ulcers.
  • To compare relapse rates between current smokers, ex-smokers, and non-smokers.
  • To assess the effect of smoking cessation during maintenance treatment on ulcer relapse.

Main Methods:

  • A cohort of 1899 patients with healed duodenal ulcers were enrolled.
  • Patients received 150 mg ranitidine daily for one or two years.

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  • Relapse rates were monitored and compared based on smoking history (current, ex-, non-smoker) and smoking cessation during treatment.

    • Main Results:

    • The two-year relapse rate was 23.4% for smokers versus 18.0% for non-smokers, a statistically significant difference.
    • Ex-smokers had a relapse rate of 26.3%.
    • Smokers who quit during maintenance had a significantly lower relapse rate (14.2%) compared to those who continued smoking (25.2%).

    Conclusions:

    • Continued and past smoking significantly increase the two-year relapse rate of duodenal ulcers.
    • Smoking cessation during ranitidine maintenance therapy is associated with a reduced risk of duodenal ulcer relapse.
    • These findings underscore the importance of addressing smoking in the management of duodenal ulcer disease.