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Macromolecular drugs

P Ferruti

    Il Farmaco; Edizione Scientifica
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study explores pharmacologically active synthetic polymers, detailing their design and synthesis. Key examples include polymers for heparin complexation, prostaglandin release, and nicotinic acid delivery.

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    Area of Science:

    • Polymer chemistry
    • Pharmacology
    • Biomaterials science

    Background:

    • Synthetic polymers offer potential for controlled drug delivery and therapeutic applications.
    • Designing polymers with specific pharmacological activities requires careful consideration of chemical structure and properties.

    Purpose of the Study:

    • To discuss the principles and chemical design aspects of pharmacologically active synthetic polymers.
    • To describe the synthesis and properties of specific functional polymers.

    Main Methods:

    • Review of principles for designing pharmacologically active synthetic polymers.
    • Synthesis and characterization of heparin-complexing polymers.
    • Synthesis and characterization of prostaglandin-releasing polymers.
    • Synthesis and characterization of nicotinic acid-releasing polymers.

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    Main Results:

    • Demonstrated principles for designing polymers with targeted pharmacological activities.
    • Successfully synthesized and characterized polymers capable of complexing heparin.
    • Developed polymers for the controlled release of prostaglandin.
    • Created polymers for the controlled release of nicotinic acid.

    Conclusions:

    • Pharmacologically active synthetic polymers represent a promising area for therapeutic development.
    • The described synthetic strategies enable the creation of functional polymers for specific medical applications.