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Lack of efficacy of clozapine monotherapy in refractory obsessive-compulsive disorder
C J McDougle1, L C Barr, W K Goodman
1Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.
Objective:
The authors assessed the efficacy of clozapine monotherapy for adults with treatment-resistant obsessive-compulsive disorder.
Method:
Twelve adults with refractory obsessive-compulsive disorder participated in a 10-week, open-label, systematic trial of clozapine. They were assessed with the Yale-Brown Obsessive Compulsive Scale, the Hamilton Depression Rating Scale, and the global improvement item of the Clinical Global Impression (CGI) scale.
Results:
None of the 10 patients who completed the trial was a responder. No significant change was observed in obsessive-compulsive or depressive symptoms or in scores on the CGI global improvement item.
Conclusions:
These findings suggest that clozapine monotherapy is not effective for most adult patients with treatment-resistant obsessive-compulsive disorder.