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[Genetics of vitiligo]

J P Lacour1, J P Ortonne

  • 1Service de Dermatologie, Hôpital Pasteur, Nice.

Annales De Dermatologie Et De Venereologie
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Vitiligo is a genetically influenced skin condition. Research indicates multiple genes likely contribute to its development, affecting melanocyte survival and growth, though specific genes remain unidentified.

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Area of Science:

  • Dermatology
  • Genetics
  • Immunology

Context:

  • Vitiligo is a complex skin depigmentation disorder.
  • Evidence suggests a significant genetic component in vitiligo pathogenesis.
  • Animal models and familial studies support a hereditary basis.

Purpose:

  • To review the genetic evidence supporting vitiligo as a genetically dependent disease.
  • To explore potential genetic factors influencing melanocyte function and autoimmune responses in vitiligo.
  • To highlight the ongoing search for specific genes implicated in vitiligo.

Summary:

  • Vitiligo exhibits genetic influences, supported by animal models, familial clustering, and twin studies.
  • While human leukocyte antigen (HLA) associations are inconsistent, intrinsic melanocyte abnormalities persist.

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  • Vitiligo is likely polygenetic, involving genes for melanocyte death, growth regulation (e.g., keratinocyte melanotrophic factor), and autoimmunity.

    • Impact:

    • Understanding the genetic basis of vitiligo is crucial for developing targeted therapies.
    • Identifying specific genes could elucidate disease mechanisms and improve diagnostic approaches.
    • This review underscores the need for further molecular genetic research to pinpoint causative genes.