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Striatal dopaminergic denervation in pallidopyramidal disease demonstrated by positron emission tomography
P Remy1, H Hosseini, J D Degos
1Commissariat à l'Energie Atomique, Service Hospitalier Frédéric Joliot, Orsay, France.
Annals of Neurology
|December 1, 1995
Abstract:
Pallidopyramidal disease is a rare disease of young patients in which they manifest a parkinsonian syndrome and pyramidal signs. Pallidopyramidal disease has been attributed to a degeneration of the pallidum and the pyramidal tract, although only 1 patient has been studied postmortem. In the present report, [18F]fluorodopa positron emission tomography in 2 patients showed a marked dopaminergic denervation of the striatum, suggesting that this disease corresponds more to a nigropallidopyramidal dysfunction.