Combined valve replacement and coronary bypass grafting in osteogenesis imperfecta

Area of Science:

• Cardiology
• Cardiac Surgery
• Genetics

Background:

• Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by brittle bones.
• Open cardiac procedures in OI patients typically have high mortality rates.
• OI patients often require multiple surgical interventions, including cardiac and orthopedic procedures.

Observation:

• A patient diagnosed with osteogenesis imperfecta presented for cardiac surgery.
• The patient had planned orthopedic surgery requiring cardiac clearance.
• The patient had significant cardiac comorbidities necessitating intervention.

Findings:

• The patient successfully underwent aortic valve replacement.
• Coronary artery bypass grafting was successfully performed.
• Closure of a patent foramen ovale was achieved concurrently.
• The patient tolerated the complex cardiac procedure well.

Implications:

• This case demonstrates the feasibility of complex open cardiac surgery in OI patients.
• Successful cardiac intervention can facilitate subsequent orthopedic procedures in OI.
• Improved surgical strategies may reduce mortality in osteogenesis imperfecta patients undergoing major surgery.
• This case highlights the importance of multidisciplinary care for patients with rare genetic disorders.