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Retinoids as teratogens
1Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Annual Review of Nutrition
|January 1, 1995
Summary
High doses of retinoids during pregnancy can cause birth defects (teratogenesis). This review covers fetal malformations, retinoid pharmacology, and the molecular mechanisms behind these developmental issues.
Area of Science:
- Developmental Toxicology
- Pharmacology
- Molecular Biology
Background:
- Vitamin A is essential, but retinoids can be teratogenic.
- Maternal retinoid intake is linked to fetal malformations.
Purpose of the Study:
- To review teratogenesis from maternal retinoid ingestion.
- To examine retinoid pharmacology and molecular mechanisms.
Main Methods:
- Literature review of animal and human studies.
- Analysis of retinoid structure-function and pharmacokinetics.
- Examination of molecular mechanisms and gene targets.
Main Results:
- Teratogenic effects of retinoids are well-documented in various species.
- Pharmacological properties influence teratogenic potential.
- Molecular pathways involving retinoic acid receptors are implicated.
Conclusions:
- Understanding retinoid teratogenesis is crucial for maternal and fetal health.
- Further research into molecular mechanisms can inform safety guidelines.
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