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Related Experiment Videos

Cellular copper transport

C D Vulpe1, S Packman

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0748, USA.

Annual Review of Nutrition
|January 1, 1995
PubMed
Summary
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Cellular copper transport is vital for all life, involving import, detoxification, and export mechanisms. Studying human diseases revealed conserved copper-transporting ATPases across species.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Genetics

Background:

  • Cellular copper transport is essential for all organisms, balancing utilization and preventing toxicity.
  • Copper import involves proteins with metal-binding and catalytic domains.
  • Detoxification strategies include binding to proteins like metallothioneins and compartmentalization.

Purpose of the Study:

  • To explore the conserved mechanisms of cellular copper transport across different species.
  • To identify proteins involved in copper import, intracellular transfer, and export.
  • To understand the role of copper transport in human genetic disorders.

Main Methods:

  • Comparative analysis of copper transport proteins in bacteria, yeast, and mammals.
  • Investigation of human copper transport disorders (Menkes and Wilson disease).

Related Experiment Videos

  • Identification of conserved protein domains and functional motifs.

    • Main Results:

    • Copper import requires proteins with both metal-binding and catalytic functions.
    • Detoxification involves metallothioneins and intracellular compartment transfer.
    • Menkes and Wilson disease genes encode conserved P-type copper-transporting ATPases.

    Conclusions:

    • Copper transport mechanisms are highly conserved from unicellular organisms to mammals.
    • P-type ATPases play a crucial role in cellular copper export.
    • Homologues of yeast and bacterial copper transport proteins likely exist in mammalian systems.