Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Specific decrease of Th1-like activity in mice with plasma cell tumors

M C Ruzek1, A Mathur

  • 1Department of Microbiology, University of Minnesota, Minneapolis 55455, USA.

International Immunology
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design of twin delayed deep deterministic policy gradient RL based adaptive controller for DC motor speed regulation considering uncertainties.

Scientific reports·2026
Same author

Association between passive smoking and oral health among children: an umbrella review.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2025
Same author

Comment on "Comparison of cone beam computed tomography and panoramic imaging for the detection of pneumatization of the articular eminence".

International journal of oral and maxillofacial surgery·2025
Same author

Comment on "Analysis of device survival and predictive factors in a cohort of patients undergoing male artificial urinary sphincter implantation".

Actas urologicas espanolas·2025
Same author

Airport microgrid control using integral-of-absolute-error having high renewable penetration.

Scientific reports·2025
Same author

Comment on "Exploring the correlation between high-risk coronary plaque and hepatic fat fraction in non-alcoholic fatty liver disease using spectral CT".

Clinical radiology·2025
Same journal

Thymic cortical epithelial Psmb11-encoded β5t in mouse and human.

International immunology·2026
Same journal

Signaling and Transcriptional Control of Thymocyte Differentiation.

International immunology·2026
Same journal

17,18-epoxyeicosatetraenoic acid and its metabolite attenuate IL-33-induced airway inflammation involving group 2 innate lymphoid cells.

International immunology·2026
Same journal

FcμR enhances recall responses by promoting the generation of CD80+PD-L2+ memory B cells.

International immunology·2026
Same journal

Mitochondrial Transfer-Driven Immune Evasion in the Tumor Microenvironment.

International immunology·2026
Same journal

Granulocyte heterogeneity in immune-mediated and inflammatory diseases: Insights from single-cell transcriptomic analyses.

International immunology·2026
See all related articles

Plasma cell tumors impair host immune responses by reducing T-cell proliferation and inhibiting T-helper 1 (Th1) cytokine production, specifically interleukin-2 (IL-2) and interferon-gamma (IFN-γ). This study reveals how tumors affect crucial immune cell functions.

Area of Science:

  • Immunology
  • Cancer Biology
  • Tumor Immunology

Background:

  • Host immune responses play a role in regulating immunoglobulin (Ig) production.
  • Previous research examined immune regulation of Ig production in a murine plasma cell tumor model (B53).
  • This study investigates the reciprocal effects of plasma cell tumors on host immune responses.

Purpose of the Study:

  • To determine the impact of plasma cell tumors on host immune cell proliferation and cytokine production.
  • To identify which immune cell populations and T-helper subsets are affected by the tumor.
  • To understand the mechanisms by which tumors modulate the host immune system.

Main Methods:

  • Murine plasma cell tumor models were used to study host immune responses.

Related Experiment Videos

  • Splenocyte proliferation was assessed using polyclonal mitogens like Concanavalin A (Con A) and phorbol 12-myristate 13-acetate (PMA) with calcium ionophore (A23187).
  • Flow cytometry was used to fractionate splenocytes into CD4+ and CD8+ T cells.
  • Cytokine production (IL-2, IFN-γ, IL-4, IL-10) from stimulated splenocytes and T cells was measured to assess Th1 and Th2 responses.

    • Main Results:

    • Splenocytes from tumor-bearing mice showed significantly reduced proliferation compared to controls.
    • This decreased proliferation was specifically observed in CD4+ T cells, while CD8+ T cell proliferation remained unaffected.
    • Production of Th1 cytokines, including IL-2 and IFN-γ, was significantly lower in stimulated splenocytes and T cells from tumor-bearing mice.
    • No significant alterations in Th2 cytokine production (IL-4 and IL-10) were detected.

    Conclusions:

    • Plasma cell tumors exert down-modulatory effects on host immune responses.
    • The tumors inhibit Th1-mediated immune responses, characterized by reduced IL-2 and IFN-γ production.
    • CD4+ T cells are a primary target of tumor-induced immunosuppression, while CD8+ T cell function appears preserved.