NAD glycohydrolases and the metabolism of cyclic ADP-ribose
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M K Jacobson1, D Cervantes-Laurean, M S Strohm
1Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 76107, USA.
Biochimie
|January 1, 1995
Abstract:
Cyclic ADP-ribose is a recently discovered metabolite of NAD that functions in cellular calcium signalling. The discovery that NAD glycohydrolases can catalyze the synthesis and hydrolysis of cyclic ADP-ribose has renewed interest in this class of ADP-ribose transferring enzymes that were discovered over 50 years ago.